BEVERLY HILLS, Calif. -- The recession-era tale "Up in the Air" led Golden Globe film contenders Tuesday with six nominations, among them best drama and acting honors for George Clooney, Vera Farmiga and Anna Kendrick.

Other drama picks were the space fantasy "Avatar," the Iraq War tale "The Hurt Locker," the World War II saga "Inglourious Basterds" and the Harlem drama "Precious: Based on the Novel 'Push' by Sapphire."

The musical "Nine" ran second with five nominations, including best musical or comedy and acting slots for Daniel Day-Lewis, Penelope Cruz and Marion Cotillard.

Also competing for musical or comedy are the romance "(500) Days of Summer," the bachelor-party bash "The Hangover" and two Meryl Streep films, "It's Complicated" and "Julie & Julia."

"Up in the Air" generally has been considered a comedy, but its inclusion in the drama category could give it more weight as a potential favorite for the Academy Awards, where dramatic films tend to dominate. The film also earned best-director and screenplay nominations for Jason Reitman.

Playing a frequent-flyer junkie in "Up in the Air," Clooney had a nomination for best dramatic actor, along with Jeff Bridges as a boozy country singer in "Crazy Heart," Colin Firth as a grieving gay academic in "A Single Man," Morgan Freeman as Nelson Mandela in "Invictus" and Tobey Maguire as a prisoner of war in "Brothers."

Streep had two nominations for musical or comedy actress, as chef Julia Child in "Julie & Julia" and a woman in an affair with her ex-husband in "It's Complicated."

Sandra Bullock also had two nominations, as dramatic actress in the football story "The Blind Side" and as a dragon-lady boss forcing her assistant to pose as her fiance in "The Proposal."

Matt Damon picked up two nominations, as well, as musical or comedy actor playing a whistleblower spinning wild fabrications in "The Informant!" and as supporting actor playing a South African rugby star in "Invictus."

Other dramatic actress nominees were Emily Blunt as Britain's monarch in her early reign in "The Young Victoria," Helen Mirren as the imperious wife of Leo Tolstoy in "The Last Station," Carey Mulligan as a 1960s British teen in an affair with an older man in "An Education" and Gabourey Sidibe as an illiterate, abused teen turning her life around in "Precious."

Julia Roberts was a surprise nominee for musical or comedy actress as a corporate spy in "Duplicity," a box-office underachiever that generally was not on the awards radar. Along with Roberts, Streep and Bullock, Cotillard rounded out the category as the wife of an unfaithful filmmaker in "Nine."

Day-Lewis as the "Nine" filmmaker scored a nomination for musical or comedy actor. Besides Damon, the category also includes Robert Downey Jr. as the London detective in "Sherlock Holmes," Joseph Gordon-Levitt as a lovesick man in "(500 Days of Summer" and Michael Stuhlbarg as a 1960s Jewish academic besieged by crises in "A Serious Man."

"Up in the Air" co-stars Farmiga, playing Clooney's frequent-flyer soul mate, and Anna Kendrick, playing a smart but inexperienced efficiency expert, are competing against each other for supporting actress. Also nominated are Cruz as the filmmaker's insecure mistress in "Nine," Mo'Nique as a hateful welfare mother in "Precious" and Julianne Moore as a grief-stricken professor's best pal in "A Single Man."

The 67th annual Globes will be handed out Jan. 17, six days before nomination voting closes for the Oscars.