Villanova's Dwayne Anderson dunks over American's Jordan Nichols (44) and Brian Gilmore (14) in the in Philadelphia, Thursday. Villanova won 80-67.
Villanova’s Dwayne Anderson dunks over American’s Jordan Nichols (44) and Brian Gilmore (14) in the in Philadelphia, Thursday. Villanova won 80-67.

PHILADELPHIA — Dwayne Anderson and Dante Cunningham each scored 25 points, and Villanova rallied back from a 14-point hole to beat upset-minded American 80-67 in the first round of the NCAA tournament Thursday night.

The third-seeded Wildcats (27-7) lost their home-court advantage and nearly lost the game, needing a late 19-2 run in the East Regional to fend off the Patriot League champions.

The 14th-seeded Eagles (24-8) sizzled from 3-point range early and pushed Villanova to the brink of a monumental upset. They just didn’t have enough left in their tired legs down the stretch, something the Wildcats exploited in their game-changing spurt.

The loss ended the Eagles’ 13-game winning streak, the second-longest in the country.

Garrison Carr scored 22 points, Derrick Mercer had 17 and Brian Gilmore 16 for American, whose senior starters not only wanted to leave it all on the floor, they never wanted to leave the floor. Mercer played 40 minutes and Carr (37) and Gilmore (36) were right behind.

The Wildcats will play the UCLA-Virginia Commonwealth winner on Saturday.

For 30 minutes, American was poised to escape with the win in only the program’s second NCAA tournament game.

But Anderson and Cunningham, part of the winningest senior class in Villanova history, refused to let that happen.

Anderson hit a 3-pointer for a 58-55 lead with 6:21 left that brought the Wildcats all the way back from their big deficit. Cunningham followed with a layup and Villanova was shifting into another gear while the Eagles were tiring.

American built its lead on 3-pointers, going 8-for-15 in the first half, before fizzling the rest of the way.

They only went to the free-throw line five times, while Villanova made 26 of 29 attempts and chipped into the lead. Corey Fisher made four during Villanova’s big run trim the gap to four, and Scottie Reynolds, a non-factor for most of the game, finally tied it for Villanova on a driving layup that made it 55-all.